Data input

Input files of the metabolome data(.csv) consists of: sample name (at the first column. If you also upload the microbiome data, which must be the same as the sample name in microbiome data), metabolites name (at the first row) ,metabolome data. The sample is as follows:
Deoxyuridine4-Pyridoxic acid2-Hydroxybutyric acid1-Methylhistidine
sample134.165.434.765.6
sample252.453.632.465.1
sample333.256.432.122.2
sample455.382.534.224.6
sample565.133.134.215.2

.csv file. You must upload at least one of the metabolome data or the microbiome data for further analysis

Input files of the microbiome data(.csv) consists of: sample name (at the first column. If you also upload the metabolome data, which must be the same as the sample name in metabolome data), microbes name (at the first row) ,microbiome data. The sample is as follows:
BifidobacteriumEggerthellaBacteroidetesParabacteroides
sample10.270.650.340.65
sample20.540.530.460.18
sample30.520.560.410.82
sample40.630.860.620.68
sample50.140.610.420.65

.csv file. You must upload at least one of the metabolome data or the microbiome data for further analysis

Optional. Input files of the phenotype data(.csv) consists of: sample name (at the first column, which must be the same as the sample name in others data), microbes name (at the first row) ,microbiome data. The sample is as follows:

Phenotype (Categorical):

Phenotype
sample1A
sample2A
sample3B
sample4B
sample5B

Phenotype (Continuous):

Phenotype
sample12.4
sample24.3
sample35.3
sample45.2
sample54.2

.csv file.

Input files of the microbiome data(.csv) consists of: sample name (at the first column. If you also upload the metabolome data, which must be the same as the sample name in metabolome data), microbes name (at the first row) ,microbiome data. The sample is as follows:
Weight
sample166
sample256
sample377
sample478
sample552

.csv file.

Newborns
The gut microbiome and metabolome in 19 African-American newborns were investigated using fecal samples collected in the first few days (from 2 min to 176 h after birth) of life. The metagenomic sequences (derived from Illumina HiSeq) and the metabolome data (derived from LC-MS) were used. The sampling time (hour) after birth was taken as a continuous phenotype. The mother’s BMI was taken as a confounding factor.
Diabetes Patients
Bile acids (quantified metabolome) and high abundance genera (16S rRNA microbiome) derived from the fecal samples of 18 healthy controls (C) and 29 diabetics (D) were used here. A binary categorical variable (C vs. D) was taken as the phenotype and BMI was taken as a confounding factor.